Alkylating Antineoplastics

《英文msh詞典》Alkylating Antineoplastics
[入口詞] Alkylating Antineoplastics
[主題詞] Antineoplastic Agents,Alkylating
[英文釋義] A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups,that after metabolism,can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA,Drug Evaluations Annual,1994,p2026)